You can deploy an Akka gRPC application just like you would any other JVM-based project. For some general pointers on this topic, see the deployment section of the Akka documentation.
Remember that the cleartext HTTP/2 “h2c with prior knowledge” protocol is not compatible with HTTP/1.1, so if your infrastructure uses any proxies they must either understand this protocol or support generic TCP connections.
When using HTTPS and running your application on a JDK 8 prior to version 1.8.0_251 you also need to provide an external ALPN implementation. Follow the section on ALPN in the Akka-HTTP docs for more details.
As an example, here is a complete project consisting of two applications (a gRPC service and an HTTP service that consumes the gRPC service) that can be deployed together in Kubernetes.